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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

Pregnancy or nursing Not recommended for women who are pregnant, planning to become pregnant, or breastfeeding

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"Research chemical" peptides from unregulated sources carry additional risks unknown purity, incorrect concentrations, contamination

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